Fluorescent Probe for Oral Cancer

UC Davis researchers have developed a laser probe for the early detection of oral cancer. A trial with human subjects shows that the device could also be used during surgery to locate the edges of a tumor.

Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage.

"There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening."

Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe.

The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present.

During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue.

Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings from spectroscopy with biopsy samples from the same locations and found that the probe could accurately diagnose the cancer in the surgical environment.

The probe is similar to one that Marcu has already developed for use with brain tumors. In clinical trials, surgeons have used her technology to delineate the margins of tumors during surgery.

Details of the human oral cancer study will be published in an upcoming issue of the journal Otolaryngology -- Head and Neck Surgery. The pilot study in patients was supported in part by the Cancer Center and the Clinical and Translational Science Center at the UC Davis School of Medicine and the UC Davis Center for Biophotonics Science and Technology.

Fluorescent Probe for Oral Cancer

UC Davis researchers have developed a laser probe for the early detection of oral cancer. A trial with human subjects shows that the device could also be used during surgery to locate the edges of a tumor.

Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage.

"There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening."

Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe.

The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present.

During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue.

Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings from spectroscopy with biopsy samples from the same locations and found that the probe could accurately diagnose the cancer in the surgical environment.

The probe is similar to one that Marcu has already developed for use with brain tumors. In clinical trials, surgeons have used her technology to delineate the margins of tumors during surgery.

Details of the human oral cancer study will be published in an upcoming issue of the journal Otolaryngology -- Head and Neck Surgery. The pilot study in patients was supported in part by the Cancer Center and the Clinical and Translational Science Center at the UC Davis School of Medicine and the UC Davis Center for Biophotonics Science and Technology.

Tongue Cancer Remedies

PATIENT-My father has cancer of the tongue; he is 75. Doctors have advised surgery. I am worried that surgery at his age may be risky. Is there an alternative therapy which may help?
SUGGESTED SOLUTIONS
Tongue cancer, because of its very location, can affect day-to-day life and would require surgery if your father’s daily intake of food is at risk. It also depends on the stage of the cancer and its spread. Otherwise, considering his age, it is best to consult a good Homeopathic doctor
Ayurveda
You can try taking Rasagandhi mezhuku orally. While using this medicine, avoid spicy food, non-vegetarian foods and white pumpkin (ashgourd)
Homeopathy
Crotalus horridus is one of the specific remedies for mouth cancer while others such as Hydrastis, Arsenicum album, Carcinocin, Condurango, Apis mel and Merc sol are also used for treatment.

                            Tongue Cancer Remedies

PATIENT-My father has cancer of the tongue; he is 75. Doctors have advised surgery. I am worried that surgery at his age may be risky. Is there an alternative therapy which may help?
SUGGESTED SOLUTIONS
Tongue cancer, because of its very location, can affect day-to-day life and would require surgery if your father’s daily intake of food is at risk. It also depends on the stage of the cancer and its spread. Otherwise, considering his age, it is best to consult a good Homeopathic doctor
Ayurveda
You can try taking Rasagandhi mezhuku orally. While using this medicine, avoid spicy food, non-vegetarian foods and white pumpkin (ashgourd)
Homeopathy
Crotalus horridus is one of the specific remedies for mouth cancer while others such as Hydrastis, Arsenicum album, Carcinocin, Condurango, Apis mel and Merc sol are also used for treatment.

Oral Cancer

Cancer is the second leading cause of death after cardio–vascular disease and cancer of the oral cavity and pharynx accounts for 2.5% of all cases. Between 90 and 95% of all oral cancers arise from the flattened Squamous cells that line the mouth’s soft tissues. When these cells grow out of control, they form a malignant tumor known as a Squamous cell carcinoma.

Most of the sores, lumps or red and white patches seen or felt in the mouth or around the lip are not cancerous. They are usually caused by cheek and tongue biting, hypersensitivity, infections or rough teeth and dentures. If these irritations do not heal within a couple of weeks, they should be looked at by a dentist or physician. Early detection of oral cancer followed by immediate treatment can often lead to a complete cure.

Although oral and pharyngeal cancer is one of the most preventable of all cancers, the mortality rates are very high. The fact that it is most amenable to early detection emphasizes the importance of the clinician’s knowledge of risk factors and clinical manifestations for oral cancer.